Cyclophosphamide
نویسندگان
چکیده
منابع مشابه
Clinical pharmacology of cyclophosphamide.
stools were determined by liquid scintillation counting. Plasma and urine alkylating activity was measured by reaction with 4-(4-nitrobenzyl)pyridine. Protein binding of cyclophosphamide and plasma alkylating metabolites were deter mined by plasma ultrafiltration. Injected Cyclophosphamide distributed rapidly into 64% of body weight, and plasma Cyclophosphamide half-life in patients without pri...
متن کاملRenal transplantation under cyclophosphamide.
BEGINNING 15 mo ago, at the University of Colorado, the alkylating agent, cyclophosphamide (Cytoxan), has been given an extensive clinical trial in the treatment of whole organ recipients both early and late after transplantation. This communication will deal only with those cases of renal homotransplantation in which cyclophosphamide was used from the outset. The late substitution of cyclophos...
متن کاملCyclophosphamide Resistance in Medulloblastoma1
Mechanisms of tumor resistance to 4-hydroperoxycyclophosphamide (4-HC) were studied by using a panel of human medulloblastoma cell lines either passaged in the laboratory for resistance to 4-HC or estab lished from tumors showing clinical resistance to cyclophosphamide. Multiple distinct mechanisms of resistance were demonstrated. Daoy (4-HCR), a line that was 6-fold more resistant than Daoy, c...
متن کاملCyclophosphamide-Induced Cardiomyopathy
Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis. In this review, we present a case of cyclophosphamide-induced cardiomyopathy requiring mechanical circulatory support. We also describe the pathophysiology, clinical manifestations, and ris...
متن کاملCyclophosphamide-induced chimerism.
BALB/c mice were injected with cyclophosphamide (Cytoxan) (180-280 mg/kg) i.p., and with 3 X 10T (BALB/c 9 X DBA a ) Fj (CDF) spleen cells i.v. The recipients were bled periodically and their sera tested for DBA y-globulin. All mice had levels of donor y-globulin at 2 weeks; 17/24 still had detectable levels at 6 months. A greater proportion of mice had detectable donor y-globulin for a longer ...
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ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-95020-8